Bonita R. Beaglehole R. Kjellstrom T. Basic epidemiology. World Health Organization, Geneva, Switzerland2006 Epidemiology: principles and methods. Little, Brown, and Company, Boston, MA1970 US Centers for Disease Control and Prevention () () Broder I. Higgins M.W. Mathews K.P. Keller J.B. Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan. IV. Natural
0 Comments People line up to get on the Air France flight to Paris at OR Tambo’s airport in Johannesburg, South Africa, on Nov. 26. The United States, Israel and other European nations have already imposed travel restrictions on South Africa and other nations in the region. Jerome Delay/AP hide caption toggle caption Jerome Delay/AP People
0 Comments Asthma is a chronic inflammation of the airways primarily mediated by exacerbated type 2 immune responses. 1 The immunology of asthma. , 2 Lloyd C.M. Snelgrove R.J. Type 2 immunity: expanding our view. Sex differences in asthma prevalence and phenotypes have been well described. 3 Carey M.A. Card J.W. Voltz J.W. Arbes Jr., S.J.
0 Comments×600/public/Boris_Johnson_MSC_2019_cropped_i.jpg?h=4826150d Cases of the omicron variant of the coronavirus popped up in countries on opposite sides of the world Sunday and many governments rushed to close their borders even as scientists cautioned that it’s not clear if the new variant is more alarming than other versions of the virus. The variant was identified days ago
0 Comments Pape K. Ryttergaard L. Rotevatn T.A. Nielsen B.J. Torp-pedersen C. Overgaard C. et al. Leisure-time physical activity and the risk of suspected bacterial infections. Med Sci Sport Exerc. 2019; 48: 1737-1744 Kostka T. Berthouze S. Lacour J. Bonnefoy M. The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sport
0 Comments The news about a new Covid variant, which is generating massive media interest under the name Omikron, has reached the end of the week shook both the stock and the crypto market. The Omikron, which is based on the Ethereum Layer 2 solution Arbitrum, has not only shown itself to be unimpressed. Omikron is
0 Comments IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined. Source link
0 Comments Background Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date, the use of HPO has
0 Comments Manthiram K. Zhou Q. Aksentijevich I. Kastner D.L. The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. Nat Immunol. 2019; 18: 832-842 Nigrovic P.A. Lee P.Y. Hoffman H.M. Monogenic autoinflammatory disorders: conceptual overview, phenotype, and clinical approach. J Allergy Clin Immunol. 2020; 146: 925-937 The scary world of variants of
0 Comments President Biden speaks to media as he arrives on Air Force One at Andrews Air Force Base, Md., on Sunday after returning from Nantucket, Mass., after spending the Thanksgiving holiday there. Carolyn Kaster/AP hide caption toggle caption Carolyn Kaster/AP President Biden speaks to media as he arrives on Air Force One at Andrews Air
0 Comments Footnotes This work in this study was funded by the National Institute of Allergy and Infectious Diseases through the Inner City Asthma Consortium ( UM1 AI11427 ). Disclosure of potential conflict of interest: All authors with the exception of P. Gergen, and A. Togias report grants from National Institutes of Health (NIH)/National Institute of
0 Comments Harty J.T. Tvinnereim A.R. White D.W. CD8+ T cell effector mechanisms in resistance to infection. Annu Rev Immunol. 2000; 18: 275-308 View in Article Scopus (520) PubMed Crossref Google Scholar Kägi D. Ledermann B. Bürki K. Seiler P. Odermatt B. Olsen K.J. et al. Cytotoxicity mediated by T cells and natural killer cells is
0 Comments There is an ongoing debate as to whether asset management is the most important undertaking in enterprise cybersecurity or if it’s just a small but important piece of a much bigger risk reduction puzzle. Proponents will argue that no organization can proactively protect against threats and manage vulnerabilities, and accelerate incident response, if it
0 Comments Activated phosphoinositide 3-kinase (PI3K) delta syndrome (APDS) was first described in 2019, with heterozygous mutations in PI3Kδ catalytic p110δ (PIK3CD) or regulatory p85α (PIK3R1) subunits leading to APDS1 and APDS2, respectively. 1 Angulo I. Vadas O. Garcon F. Banham-Hall E. Plagnol V. Leahy T.R. et al. Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory
0 Comments Background Atopic keratoconjunctivitis (AKC) is a chronic allergic conjunctival disease. However, a mouse model of AKC to investigate the underlying mechanism of the therapeutic agents and estimate their efficacy has not been established. We recently generated mice in which Ikk2 is specifically deleted in facial skin fibroblasts and found that these mice spontaneously develop
0 Comments Following the discovery of a new COVID-19 variant, the United Kingdom imposed new restrictions on arriving travelers from South Africa and other southern African countries. The U.S. is implementing similar restrictions starting Monday. Hollie Adams/Getty Images hide caption toggle caption Hollie Adams/Getty Images Following the discovery of a new COVID-19 variant, the United Kingdom
0 Comments Footnotes This consensus was supported and facilitated by the Global Allergy and Asthma European Network (GA2LEN), which received an unrestricted grant from Shire (a member of the Takeda group of companies). The funding body had no input into the development of the voting statements, the analysis or interpretation of the results, or the decision to
0 Comments Background A novel autoinflammatory syndrome was recently described in male patients who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytopenia, dysplastic bone marrow, vacuoles in myeloid and erythroid progenitor cells, cutaneous and pulmonary inflammation, chondritis, and vasculitis, which is abbreviated as VEXAS. Objective
0 Comments Background Binding IgE to a cognate allergen causes aggregation of Fcε receptor I (FcεRI) in mast cells, resulting in activation of receptor-associated Src family tyrosine kinases, including Lyn and Syk. Protein tyrosine phosphatase, receptor type C (PTPRC), also known as CD45, has emerged as a positive regulator of FcεRI signaling by dephosphorylation of the
0 Comments The etiology of food allergy is poorly understood; mouse models are powerful systems to discover immunologic pathways driving allergic disease. C3H/HeJ mice are a widely used model for the study of peanut allergy because, unlike C57BL/6 or BALB/c mice, they are highly susceptible to oral anaphylaxis. However, the immunologic mechanism of this strain’s susceptibility
0 Comments   In the span of a little more than two weeks, a new Covid-19 strain advanced from its first known infection to classification as a variant of concern. Understanding the extent of the threat posed by the new variant Omicron and responding to it will take more time. Analysis of Omicron so far found
0 Comments Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers of varying molecular weight (MW) used as excipients in many different products, including drugs and cosmetics. 1 Immediate-type hypersensitivity to polyethylene glycols: a review. PEGs have recently gained renewed interest because PEG 2000 is an excipient in the BioNTech/Pfizer and Moderna mRNA vaccines against coronavirus disease
0 Comments The world’s number one digital device, bitcoin, has entered the bear market after falling 20% ​​from a historic high of around $ 69,000 as fears over the new Omicron corona virus variant have panicked the global market. The price of bitcoin fell below USD 54 000, a decrease of almost 8% per day. The
0 Comments As we enter 2022, the pandemic continues to exact a terrible toll in both human and economic terms. But one side effect of this crisis helped healthcare move forward dramatically: We experienced a decade’s worth of technology adaptation and adoption in the space of mere months. Tools and technologies that had been lingering (or
0 Comments Sabat R. Jemec G.B.E. Matusiak L. Kimball A.B. Prens E. Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020; 6: 18 Garg A. Kirby J.S. Lavian J. Lin G. Strunk A. Sex- and Age-adjusted population analysis of prevalence estimates for hidradenitis suppurativa in the United States. JAMA Dermatol. 2019; 153: 760-764 Dufour D.N. Emtestam
0 Comments Oncoustics CEO Beth Rogozinski. Photo credit: Oncoustics Roughly 4.5 million adults in the U.S. are estimated to have liver disease, and that number is expected to grow, as non-alcoholic fatty liver disease is on the rise. Characterized by excessive fat in the liver, it can lead to inflammation or scarring over time. Because the
0 Comments Agammaglobulinemia. Pediatrics. 1952; 9: 722-728 El-Sayed Z.A. Abramova I. Aldave J.C. Al-Herz W. Bezrodnik L. Boukari R. et al. X-linked agammaglobulinemia (XLA): phenotype, diagnosis, and therapeutic challenges around the world. World Allergy Organ J. 2019; 12100018 Vetrie D. Vorechovský I. Sideras P. Holland J. Davies A. Flinter F. et al. The gene involved in
0 Comments Effects of cortisone in the rheumatic diseases. Lancet. 1950; 2: 483-484 Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol. 2011; 25: 1075-1086 Griffin G.D. Charron D. Al-Daccak R. Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis. Clin Transl Immunology. 2019; 3: e27 Effects of glucocorticoids in the immune system.
0 Comments Heterozygous germline mutations in cytotoxic T lymphocyte–associated antigen-4 (CTLA4) impair the immunomodulatory function of regulatory T cells. Affected individuals are prone to life-threatening autoimmune and lymphoproliferative complications. A number of therapeutic options are currently being used with variable effectiveness. Source link