Immunology Background Binding IgE to a cognate allergen causes aggregation of Fcε receptor I (FcεRI) in mast cells, resulting in activation of receptor-associated Src family tyrosine kinases, including Lyn and Syk. Protein tyrosine phosphatase, receptor type C (PTPRC), also known as CD45, has emerged as a positive regulator of FcεRI signaling by dephosphorylation of the
0 Comments The etiology of food allergy is poorly understood; mouse models are powerful systems to discover immunologic pathways driving allergic disease. C3H/HeJ mice are a widely used model for the study of peanut allergy because, unlike C57BL/6 or BALB/c mice, they are highly susceptible to oral anaphylaxis. However, the immunologic mechanism of this strain’s susceptibility
0 Comments Polyethylene glycols (PEGs) or macrogols are hydrophilic polymers of varying molecular weight (MW) used as excipients in many different products, including drugs and cosmetics. 1 Immediate-type hypersensitivity to polyethylene glycols: a review. PEGs have recently gained renewed interest because PEG 2000 is an excipient in the BioNTech/Pfizer and Moderna mRNA vaccines against coronavirus disease
0 Comments Sabat R. Jemec G.B.E. Matusiak L. Kimball A.B. Prens E. Wolk K. Hidradenitis suppurativa. Nat Rev Dis Primers. 2020; 6: 18 Garg A. Kirby J.S. Lavian J. Lin G. Strunk A. Sex- and Age-adjusted population analysis of prevalence estimates for hidradenitis suppurativa in the United States. JAMA Dermatol. 2019; 153: 760-764 Dufour D.N. Emtestam
0 Comments Agammaglobulinemia. Pediatrics. 1952; 9: 722-728 El-Sayed Z.A. Abramova I. Aldave J.C. Al-Herz W. Bezrodnik L. Boukari R. et al. X-linked agammaglobulinemia (XLA): phenotype, diagnosis, and therapeutic challenges around the world. World Allergy Organ J. 2019; 12100018 Vetrie D. Vorechovský I. Sideras P. Holland J. Davies A. Flinter F. et al. The gene involved in
0 Comments Effects of cortisone in the rheumatic diseases. Lancet. 1950; 2: 483-484 Minireview: Glucocorticoids in autoimmunity: unexpected targets and mechanisms. Mol Endocrinol. 2011; 25: 1075-1086 Griffin G.D. Charron D. Al-Daccak R. Post-traumatic stress disorder: revisiting adrenergics, glucocorticoids, immune system effects and homeostasis. Clin Transl Immunology. 2019; 3: e27 Effects of glucocorticoids in the immune system.
0 Comments Heterozygous germline mutations in cytotoxic T lymphocyte–associated antigen-4 (CTLA4) impair the immunomodulatory function of regulatory T cells. Affected individuals are prone to life-threatening autoimmune and lymphoproliferative complications. A number of therapeutic options are currently being used with variable effectiveness. Source link
0 Comments Hanifin J.M. Reed M.L. Prevalence E. Group I.W. A population-based survey of eczema prevalence in the United States. Dermatitis. 2007; 18: 82-91 Shaw T.E. Currie G.P. Koudelka C.W. Simpson E.L. Eczema prevalence in the United States: data from the 2003 National Survey of Children’s Health. J Invest Dermatol. 2011; 131: 67-73 Deckers I.A.G. McLean
0 Comments Demehri S. Morimoto M. Holtzman M.J. Kopan R. Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. PLoS Biol. 2009; 7e1000067 Harada M. Hirota T. Jodo A.I. Hitomi Y. Sakashita M. Tsunoda T. et al. Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma. Am J Respir Cell Mol Biol.
0 Comments Venomous animals have developed a vast array of venom peptides for protection and predation. These peptides are invaluable resources to mankind because they are already directed to various pharmacological targets that are potentially related to pathological conditions. 1 Therapeutic potential of venom peptides. Currently, there are at least 10 Food and Drug Administration–approved drugs
0 Comments Background Observational studies have yielded inconsistent findings for the relation between vitamin D level and total IgE or allergic sensitization. Objective To determine whether vitamin D supplementation reduces levels of total IgE and IgE to each of 2 common indoor allergens in children with asthma and low vitamin D levels. Methods Total IgE, IgE
0 Comments Katoh N. Ohya Y. Ikeda M. Ebihara T. Katayama I. Saeki H. et al. Clinical practice guidelines for the management of atopic dermatitis 2019. J Dermatol. 2019; 46: 1053-1101 View in Article Scopus (33) PubMed Crossref Google Scholar Honda T. Kabashima K. Reconciling innate and acquired immunity in atopic dermatitis. J Allergy Clin Immunol.
0 Comments Fujiogi M. Goto T. Yasunaga H. Fujishiro J. Mansbach J.M. Camargo Jr., C.A. et al. Trends in bronchiolitis hospitalizations in the United States: 2000-2019. Pediatrics. 2019; 144e20192614 Kotaniemi-Syrjanen A. Vainionpaa R. Reijonen T.M. Waris M. Korhonen K. Korppi M. Rhinovirus-induced wheezing in infancy—the first sign of childhood asthma?. J Allergy Clin Immunol. 2003; 111:
0 Comments Background The efficacy of an allergen-specific IgG cocktail to treat cat allergy suggests that allergen-specific IgG may be a major protective mechanism elicited by allergen immunotherapy. Objectives Extending these findings, we tested a Bet v 1–specific antibody cocktail in birch-allergic subjects. Methods This was a phase 1, randomized, double-blind, study with 2 parts. Part
0 Comments Background Blocking the major cat allergen, Fel d 1, with mAbs was effective in preventing an acute cat allergic response. Objectives This study sought to extend the allergen-specific antibody approach and demonstrate that a combination of mAbs targeting Bet v 1, the immunodominant and most abundant allergenic protein in birch pollen, can prevent the
0 Comments Bal S.M. Golebski K. Spits H. Plasticity of innate lymphoid cell subsets. Nat Rev Immunol. 2020; 20: 552-565 Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity. Cell Res. 2020; 30: 475-491 Nussbaum J.C. Van Dyken S.J. von Moltke J. Cheng L.E. Mohapatra A. Molofsky A.B. et al. Type 2 innate lymphoid cells
0 Comments Akinbami LJ, Moorman JE, Liu X. Asthma prevalence, health care use, and mortality: United States, 2005-2009. In: US Department of Health and Human Services, ed. National Health Statistics Reports. Hyattsville, MD: National Center for Health Statistics; 2011:1-15. Nurmagambetov T. Kuwahara R. Garbe P. The economic burden of asthma in the United States, 2008-2019. Ann
0 Comments Background Noninfectious complications are the greatest cause of morbidity and mortality in common variable immunodeficiency (CVID), but their pathogenesis remains poorly defined. Objective Using high-throughput approaches, we aimed to identify, correlate, and determine the significance of immunologic features of CVID with noninfectious complications (CVIDc). Methods We simultaneously applied proteomics, RNA sequencing, and mass cytometry
0 Comments Allergen-specific immunotherapy (AIT) is currently the only disease-modifying treatment with potential curative capacity for allergy. 1 Mahler V. Esch R.E. Kleine-Tebbe J. Lavery W.J. Plunkett G. Vieths S. et al. Understanding differences in allergen immunotherapy products and practices in North America and Europe. , 2 Jensen-Jarolim E. Bachmann M. Bonini S. Jacobsen L. Jutel
0 Comments Background A relationship between adiposity and asthma has been described in some cohort studies, but little is known about trajectories of adiposity throughout early childhood among children at high risk for developing asthma in urban United States cities. Moreover, early life trajectories of adipokines that have metabolic and immunologic properties have not been comprehensively
0 Comments Hetherington S. Sarcoidosis in young children. Am J Dis Child. 1982; 136: 13-15 View in Article PubMed Google Scholar Blau E.B. Familial granulomatous arthritis, iritis, and rash. J Pediatr. 1985; 107: 689-693 View in Article Scopus (311) PubMed Abstract Full Text PDF Google Scholar Matsuda T. Kambe N. Ueki Y. Kanazawa N. Izawa K.
0 Comments Bustamante J. Boisson-Dupuis S. Abel L. Casanova J.L. Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-gamma immunity. Semin Immunol. 2019; 26: 454-470 Scopus (326) PubMed Crossref Google Scholar Jouanguy E. Altare F. Lamhamedi S. Revy P. Emile J.F. Newport M. et al. Interferon-gamma-receptor deficiency in an infant
0 Comments Food allergy among children in the United States. Pediatrics. 2009; 124: 1549-1555 Gupta R.S. Springston E.E. Warrier M.R. Smith B. Kumar R. Pongracic J. et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics. 2011; 128: e9-e17 Rona R.J. Keil T. Summers C. Gislason D. Zuidmeer L. Sodergren
0 Comments Nurmagambetov T. Kuwahara R. Garbe P. The economic burden of asthma in the United States, 2008-2019. Ann Am Thorac Soc. 2019; 15: 348-356 Zahran H.S. Bailey C.M. Damon S.A. Garbe P.L. Breysse P.N. Vital signs: asthma in children—United States, 2001-2019. MMWR Morb Mortal Wkly Rep. 2019; 67: 149-155 Akinbami L.J. Simon A.E. Rossen L.M.
0 Comments Background Tolerance development is an important clinical outcome for infants with cow’s milk allergy. Objective This multicenter, prospective, randomized, double-blind, controlled clinical study (NTR3725) evaluated tolerance development to cow’s milk (CM) and safety of an amino acid–based formula (AAF) including synbiotics (AAF-S) comprising prebiotic oligosaccharides (oligofructose, inulin) and probiotic Bifidobacterium breve M-16V in infants
0 Comments Akdis C.A. Bachert C. Cingi C. Dykewicz M.S. Hellings P.W. Naclerio R.M. et al. Endotypes and phenotypes of chronic rhinosinusitis: a PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2019; 131: 1479-1490 View in Article Scopus (391) PubMed
0 Comments Atopic dermatitis (AD) is the most common chronic inflammatory skin disease, affecting up to 20% of children and up to 10% of adults. 1 McKenzie C. Silverberg J.I. The prevalence and persistence of atopic dermatitis in urban United States children. ,  ,  3 New insights into the epidemiology of childhood atopic dermatitis. AD can
0 Comments Footnotes The first 2 authors contributed equally to this article, and both should be considered first author. Supported by grants from the Swiss National Science Foundation ( 32003B_160115/1 to A.M.S. and 32473B_185008 to E.S.), Switzerland. Disclosure of potential conflict of interest: C. Ma reports consulting fees from AVIR Pharma and Alimentiv (formerly Robarts Clinical
0 Comments In vivo animal controlled exposure 25 μL of diesel exhaust particles and influenza infection Ovalbumin-sensitized C57BL/6 mice Increased levels of lung lavage and tissue eosinophils; levels of IL-4, IL-13, CCL11, and CCR3 in lavage fluid; and levels of IL-1α in lung homogenates Jaspers et al, 15 Jaspers I. Sheridan P.A. Zhang W. Brighton L.E. Chason K.D.