http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/df14973a-116a-48ab-bc7f-17302925a32e/gr1.jpg Phenotypes and endotypes predicting optimal response to bronchial thermoplasty (BT) in patients with severe asthma remain elusive. Source link
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e3892494-7e1b-4ca1-86ed-526c45f6d258/fx1.jpg The airways of patients with obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are chronically inflamed. 1 Hoogsteden H.C. Verhoeven G.T. Lambrecht B.N. Prins J.B. Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate. Airway epithelial
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/0318515b-ffea-4fcb-a40d-aa020e100a23/fx1.jpg Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients. J Allergy Clin Immunol. 2019; 139: 1736-1751 Bonato M. Tiné M. Bazzan E. Biondini D. Saetta M. Baraldo S. Early airway pathological changes in children: new insights into the natural history of wheezing. J Clin Med. 2019; 8: 1180 Prakash Y.S. Halayko A.J.
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/f7780f80-703b-4011-8837-5395cb7d7e83/gr3.jpg Centers for Disease Control and Prevention Asthma’s impact on the nation 2019. (Available at:) (Accessed May 1, 2019) World Health Organization Asthma fact sheet 2019. (Available at:) (Accessed May 1, 2019) Mapping asthma-associated variants in admixed populations. Front Genet. 2019; 6: 292 Mathias R.A. Taub M.A. Gignoux C.R. Fu W. Musharoff S. O’Connor T.D.
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e74bbc19-33b1-4a3a-a9d8-355b401bbc25/figs1.jpg After quality control, there were 31 PN patients with transcriptomic data in both lesional and nonlesional skin samples. Using FDR ≤ 10% and |log2| ≥ 1 as criteria, we identified 5943 DEGs when comparing the uninvolved and lesional skin at baseline, of which 2060 genes were increased and 3874 decreased (Fig 1, A). Genes with the most
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/2e4d8a40-2f37-4f29-b14a-574e7f66712a/fx1.jpg Zahran H.S. Bailey C.M. Damon S.A. Garbe P.L. Breysse P.N. Vital signs: asthma in children—United States, 2001-2019. MMWR Morb Mortal Wkly Rep. 2019; 67: 149-155 View in Article PubMed Crossref Google Scholar Platts-Mills T.A. The allergy epidemics: 1870-2010. J Allergy Clin Immunol. 2019; 136: 3-13 View in Article PubMed Abstract Full Text Full Text
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/d07f0883-b2eb-450f-b6d3-3989e0a36379/gr3.jpg Cardona V. Ansotegui I.J. Ebisawa M. El-Gamal Y. Fernandez Rivas M. Fineman S. et al. World Allergy Organization anaphylaxis guidance 2020. World Allergy Organ J. 2020; 13100472 Grabenhenrich L.B. Dölle S. Ruëff F. Renaudin J.M. Scherer K. Pföhler C. et al. Epinephrine in severe allergic reactions: the European Anaphylaxis Register. J Allergy Clin Immunol
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/31dec6b6-7fd3-40b4-ad7c-3c1210607f18/gr3.jpg Here, we characterize the metabolomic and lipidomic derangements in a patient with mastocytosis during severe MC activation. This patient was treated in the intensive care unit and had acute life-threatening symptoms for several hours. Discussion The BL histamine concentrations in this patient with mastocytosis are approximately 4 ng/mL, compared with a peak of 30
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/5e075af4-3693-42ff-a97f-402fe3e035ca/gr1.jpg Background Most patients with childhood-onset immune dysregulation, polyendocrinopathy, and enteropathy have no genetic diagnosis for their illness. These patients may undergo empirical immunosuppressive treatment with highly variable outcomes. Objective We sought to determine the genetic basis of disease in patients referred with Immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like (IPEX-like) disease, but with no mutation in
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/ece977e4-1beb-420d-8c37-73aaff0db811/fx1.jpg Lu H.Y. Bauman B.M. Arjunaraja S. Dorjbal B. Milner J.D. Snow A.L. et al. The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex. Front Immunol. 2019; 9: 2078 Lu H.Y. Biggs C.M. Blanchard-Rohner G. Fung S.Y. Sharma M. Turvey S.E. Germline CBM-opathies: from immunodeficiency to
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/37ee9d37-69ad-4489-adf3-bca2fc68e4fe/gr3.jpg Footnotes This study was supported by the Biotechnology and Biological Sciences Research Council Studentship (BBSRC-NPIF studentship/BIDS3000032503) to Y.E.B. Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) was supported by an Innovative Medicines Initiative Joint Undertaking (no. 115010 ), resources from the European Union’s Seventh Framework Programme (FP7/2007-2019), and The European Federation of
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e971662a-743d-48f8-9c15-8bef6d3b9e6c/gr3.jpg Background Mastocytosis is a risk factor for Hymenoptera venom anaphylaxis (HVA). Current guidelines recommend measuring tryptase in patients with HVA and that those with mastocytosis pursue lifelong venom immunotherapy (VIT). Available data on HVA and mastocytosis largely derive from European single-center studies, and the prevalence of HVA with and without mastocytosis in the United
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/2ec527ec-d15b-425e-a475-ab3f4a65e23e/fx3.jpg Inborn errors of immunity (IEI) are rare diseases, which makes diagnosis a challenge. A better description of the initial presenting manifestations should improve awareness and avoid diagnostic delay. Although increased infection susceptibility is a well-known initial IEI manifestation, less is known about the frequency of other presenting manifestations. Source link
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/3008a533-ae3b-47e2-87a4-5d648a889e94/figs1.jpg Footnotes Supported by the National Psoriasis Foundation Discovery Grant 2019 and in part by grant UL1TR001866 from the National Center for Advancing Translational Sciences and the National Institutes of Health Clinical and Translational Science Award program . Disclosure of potential conflict of interest: J. Kim has received research funds from AbbVie. E. Guttman-Yassky has
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/5d998f6e-80ad-4376-bfcd-a291bbced437/fx1.jpg Food and Agriculture Organization of the United Nations; World Health Organization; Codex Alimentarius Commission General standard for the labelling of prepackaged foods. 1985. () Prescott S.L. Pawankar R. Allen K.J. Campbell D.E. Sinn J.K.h. Fiocchi A. et al. A global survey of changing patterns of food allergy burden in children. World Allergy Organ J.
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/c3afb5c6-32ad-4373-953b-b4f78c2945f5/fx1.jpg Background Exosomes have emerged as a vital player in cell-cell communication; however, whether airway epithelial cell (AEC)-generated exosomes participate in asthma development remains unknown. Objective Our aims were to characterize the AEC-secreted exosomes and the potentially functional protein(s) that may contribute to the proinflammatory effects of AEC exosomes in the dendritic cell (DC)-dominant airway
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/2c503ca6-6fe0-4cbc-80a3-528b501a110f/fx1.jpg Considering that EMT and cytoskeleton remodeling are the prerequisite processes for cell migration, 43 Cancer invasion and the microenvironment: plasticity and reciprocity. , 44 Shankar J. Messenberg A. Chan J. Underhill T.M. Foster L.J. Nabi I.R. Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. we examined whether DEP exposure was responsible for
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/13bd2120-e08e-4ed6-add2-c7d083b5fe47/gr3.jpg Bonita R. Beaglehole R. Kjellstrom T. Basic epidemiology. World Health Organization, Geneva, Switzerland2006 Epidemiology: principles and methods. Little, Brown, and Company, Boston, MA1970 US Centers for Disease Control and Prevention () () Broder I. Higgins M.W. Mathews K.P. Keller J.B. Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan. IV. Natural
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/0effa445-1f27-44d0-b364-2eb6e7790d87/fx6.jpg Asthma is a chronic inflammation of the airways primarily mediated by exacerbated type 2 immune responses. 1 The immunology of asthma. , 2 Lloyd C.M. Snelgrove R.J. Type 2 immunity: expanding our view. Sex differences in asthma prevalence and phenotypes have been well described. 3 Carey M.A. Card J.W. Voltz J.W. Arbes Jr., S.J.
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/474dfb22-a885-4cda-b4d6-c0e35dc6e88f/fx3.jpg Pape K. Ryttergaard L. Rotevatn T.A. Nielsen B.J. Torp-pedersen C. Overgaard C. et al. Leisure-time physical activity and the risk of suspected bacterial infections. Med Sci Sport Exerc. 2019; 48: 1737-1744 Kostka T. Berthouze S. Lacour J. Bonnefoy M. The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sport
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/df343833-3ee1-4447-925b-09933bc4291c/figs1.jpg IgG4-related disease (IgG4-RD) is a fibroinflammatory condition involving loss of B-cell tolerance and production of autoantibodies. However, the relevant targets and role of these aberrant humoral immune responses are not defined. Source link
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/6472ee4a-e738-45e1-8b20-c1f0d6afb361/gr3.jpg Background Accurate, detailed, and standardized phenotypic descriptions are essential to support diagnostic interpretation of genetic variants and to discover new diseases. The Human Phenotype Ontology (HPO), extensively used in rare disease research, provides a rich collection of vocabulary with standardized phenotypic descriptions in a hierarchical structure. However, to date, the use of HPO has
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/de27e469-10fc-4dfc-8a59-a6bbe76b617f/fx3.jpg Takayasu arteritis (TAK) is a large vessel vasculitis resulting in artery wall remodeling with segmental stenosis and/or aneurysm formation. Mast cells (MCs) are instrumental in bridging cell injury and inflammatory response. Source link
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e6789301-dc67-4eed-afde-6cbd83f52227/fx1.jpg Manthiram K. Zhou Q. Aksentijevich I. Kastner D.L. The monogenic autoinflammatory diseases define new pathways in human innate immunity and inflammation. Nat Immunol. 2019; 18: 832-842 Nigrovic P.A. Lee P.Y. Hoffman H.M. Monogenic autoinflammatory disorders: conceptual overview, phenotype, and clinical approach. J Allergy Clin Immunol. 2020; 146: 925-937 The scary world of variants of
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e073c0aa-7998-4872-b966-412a183fdf7a/figs1.jpg Footnotes This work in this study was funded by the National Institute of Allergy and Infectious Diseases through the Inner City Asthma Consortium ( UM1 AI11427 ). Disclosure of potential conflict of interest: All authors with the exception of P. Gergen, and A. Togias report grants from National Institutes of Health (NIH)/National Institute of
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/85629665-379a-4d34-ae4e-91b48f66994e/gr3.jpg Harty J.T. Tvinnereim A.R. White D.W. CD8+ T cell effector mechanisms in resistance to infection. Annu Rev Immunol. 2000; 18: 275-308 View in Article Scopus (520) PubMed Crossref Google Scholar Kägi D. Ledermann B. Bürki K. Seiler P. Odermatt B. Olsen K.J. et al. Cytotoxicity mediated by T cells and natural killer cells is
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/b89587b5-9164-435a-b808-6a1c743cdf6d/fx3.jpg Activated phosphoinositide 3-kinase (PI3K) delta syndrome (APDS) was first described in 2019, with heterozygous mutations in PI3Kδ catalytic p110δ (PIK3CD) or regulatory p85α (PIK3R1) subunits leading to APDS1 and APDS2, respectively. 1 Angulo I. Vadas O. Garcon F. Banham-Hall E. Plagnol V. Leahy T.R. et al. Phosphoinositide 3-kinase delta gene mutation predisposes to respiratory
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/55c310ce-8840-4f03-b124-03c3607ac321/gr3.jpg Background Atopic keratoconjunctivitis (AKC) is a chronic allergic conjunctival disease. However, a mouse model of AKC to investigate the underlying mechanism of the therapeutic agents and estimate their efficacy has not been established. We recently generated mice in which Ikk2 is specifically deleted in facial skin fibroblasts and found that these mice spontaneously develop
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/a41b7f21-129f-4e99-9ffb-2867c09758d4/gr1.jpg Footnotes This consensus was supported and facilitated by the Global Allergy and Asthma European Network (GA2LEN), which received an unrestricted grant from Shire (a member of the Takeda group of companies). The funding body had no input into the development of the voting statements, the analysis or interpretation of the results, or the decision to
http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/d636b07a-2b74-49d3-9f1b-6efba341ed36/gr1.jpg Background A novel autoinflammatory syndrome was recently described in male patients who harbored somatic mutations in the X-chromosomal UBA1 gene. These patients were characterized by adult-onset, treatment-refractory inflammation with fever, cytopenia, dysplastic bone marrow, vacuoles in myeloid and erythroid progenitor cells, cutaneous and pulmonary inflammation, chondritis, and vasculitis, which is abbreviated as VEXAS. Objective