Immunology

Development and validation of the Exercise-Induced Laryngeal Obstruction Dyspnea Index (EILODI)



http://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/66ab6570-052a-4131-b552-0aa642827ce1/gr3.jpg

Background

Exercise-induced laryngeal obstruction (EILO) causes exertional dyspnea and is important
for its effect on quality of life, diagnostic confusion with exercise-induced asthma,
and health care resource utilization. There is no validated patient-reported outcome
measure specific to EILO.

Objective

We sought to develop, validate, and define a minimal clinically important difference
for a patient-reported outcome measure to be used with adolescents and young adults
with EILO.

Methods

A multidisciplinary group created a preliminary measure, modified by a 10-member participant
focus group, with 20 items scored along a 5-point Likert scale. A subsequent cohort
of participants recruited from a clinic, aged 12 to 21 years, with confirmed EILO
by continuous laryngoscopy during exercise testing (1) completed the measure at 3
points in time over 28 days and (2) provided anchoring data in the form of a daily
exercise log and categorical self-assessments of clinical improvement. Thirty additional
participants without exertional dyspnea served as controls.

Results

Two hundred nineteen subjects with mild to severe EILO participated in the exploratory
factor analysis, which identified 7 factors within the preliminary outcome measure.
After a process of item reduction, a 12-item metric with a total score ranging from
0 to 48 was developed. Mean scores of patients with EILO and healthy controls at baseline
were 28.8 ± 7.4 and 4.5 ± 7.4, respectively. A minimal clinically important difference
of 6 was determined by comparison of index change with changes in categorical self-assessments
of improvement.

Conclusions

This is the first patient-reported outcome measure specifically designed for adolescents
and young adults with EILO.



Source link

Products You May Like

Articles You May Like

Preventing $2 million in fines – 3 things hospitals can do to ensure clarity in transparency
Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children
2 cases of the omicron variant have been identified in the United Kingdom : Coronavirus Updates : NPR
Do Tregs inhibit or promote allergic responses? How to avoid data misinterpretation
Trial Flop: Experimental Asthma Treatment Makes Symptoms Worse

Leave a Reply

Your email address will not be published. Required fields are marked *