During the height of the coronavirus disease (COVID-19) pandemic between 2019 and 2020, there was a substantial decrease in the mean number of weekly insulin prescription fills, possibly due to reduced clinic visits and loss of insurance benefits, according to study findings published in JAMA Network Open. The cross-sectional study included an analysis of
0 Comments When Greta Christina fell into a deep depression five years ago, she called up her therapist in San Francisco. She’d had a great connection with the provider when she needed therapy in the past. She was delighted to learn that he was now “in network” with her insurance company, meaning she wouldn’t have to
0 Comments People step off a tram in Nottingham, England, the city where one of the two cases of the Omicron variant of COVID-19 were identified last week. Joe Giddens – PA Images/PA Images via Getty Images hide caption toggle caption Joe Giddens – PA Images/PA Images via Getty Images People step off a tram in
0 Comments×600/public/WHO_i.jpg The World Health Organization on Monday is pushing for an international accord to help prevent and fight future pandemics amid the emergence of a worrying new omicron COVID-19 variant. WHO Director-General Tedros Adhanom Ghebreyesus also said many uncertainties remain about just how transmissible and severe infection by the highly mutated omicron might be. Tedros
0 Comments The airways of patients with obstructive airway diseases such as asthma and chronic obstructive pulmonary disease (COPD) are chronically inflamed. 1 Hoogsteden H.C. Verhoeven G.T. Lambrecht B.N. Prins J.B. Airway inflammation in asthma and chronic obstructive pulmonary disease with special emphasis on the antigen-presenting dendritic cell: influence of treatment with fluticasone propionate. Airway epithelial
0 Comments×600/public/covid-red-clinician_i.png The World Health Organization says it could still take some time to get a full picture of the threat posed by omicron, a new variant of the coronavirus as scientists worldwide scramble to assess its multiple mutations. Stock markets swooned, some public gatherings got canceled, and countries across the globe suspended incoming flights after
0 Comments It might seem like a lowest-net-cost formulary would be made up of clinically equivalent agents with the lowest overall cost. But in the complex world of drug pricing and pharmacy benefits, that is not the case. Lowest-net-cost formularies are a good way for organizations to lower their pharmacy spend. These formularies substitute clinically sound,
0 Comments Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients. J Allergy Clin Immunol. 2019; 139: 1736-1751 Bonato M. Tiné M. Bazzan E. Biondini D. Saetta M. Baraldo S. Early airway pathological changes in children: new insights into the natural history of wheezing. J Clin Med. 2019; 8: 1180 Prakash Y.S. Halayko A.J.
0 Comments The Supreme Committee for Emergencies in Yemen called on the World Health Organization and the United Nations to inform the international community and global public opinion of the restrictions imposed on measures to confront the Corona epidemic in the areas controlled by the Houthi coup militia, while continuing its refusal to vaccinate against the
0 Comments×600/public/vaccine-money_i.png The Oregon Health Authority is offering to pay pharmacies $35 for each dose of COVID-19 vaccine they administer, with the intention to boost vaccination rates. Based on the health authority’s database, 79% of people 18 years or older in Oregon have received at least their first vaccine dose. In addition, the Statesman Journal reports
0 Comments Centers for Disease Control and Prevention Asthma’s impact on the nation 2019. (Available at:) (Accessed May 1, 2019) World Health Organization Asthma fact sheet 2019. (Available at:) (Accessed May 1, 2019) Mapping asthma-associated variants in admixed populations. Front Genet. 2019; 6: 292 Mathias R.A. Taub M.A. Gignoux C.R. Fu W. Musharoff S. O’Connor T.D.
0 Comments The spread of electric bicycles was given a huge boost by the appearance of the coronavirus, as as a result of quarantines and closures, cycling became one of the forms of movement. , which could be cultivated more or less safely. However, bicycles equipped with auxiliary electric motors are becoming more and more popular
0 Comments After quality control, there were 31 PN patients with transcriptomic data in both lesional and nonlesional skin samples. Using FDR ≤ 10% and |log2| ≥ 1 as criteria, we identified 5943 DEGs when comparing the uninvolved and lesional skin at baseline, of which 2060 genes were increased and 3874 decreased (Fig 1, A). Genes with the most
0 Comments Zahran H.S. Bailey C.M. Damon S.A. Garbe P.L. Breysse P.N. Vital signs: asthma in children—United States, 2001-2019. MMWR Morb Mortal Wkly Rep. 2019; 67: 149-155 View in Article PubMed Crossref Google Scholar Platts-Mills T.A. The allergy epidemics: 1870-2010. J Allergy Clin Immunol. 2019; 136: 3-13 View in Article PubMed Abstract Full Text Full Text
0 Comments×600/public/2019-Siegel-environmental%20copy_i.jpg Like the Affordable Care Act and other landmark social spending measures before it, the human infrastructure bill now in Congress, the Build Back Better Act, would lower barriers to affordable healthcare for millions of Americans. That’s a praiseworthy goal and one that safety-net hospitals welcome as they care for the nation’s low-income and marginalized
0 Comments Cardona V. Ansotegui I.J. Ebisawa M. El-Gamal Y. Fernandez Rivas M. Fineman S. et al. World Allergy Organization anaphylaxis guidance 2020. World Allergy Organ J. 2020; 13100472 Grabenhenrich L.B. Dölle S. Ruëff F. Renaudin J.M. Scherer K. Pföhler C. et al. Epinephrine in severe allergic reactions: the European Anaphylaxis Register. J Allergy Clin Immunol
0 Comments Here, we characterize the metabolomic and lipidomic derangements in a patient with mastocytosis during severe MC activation. This patient was treated in the intensive care unit and had acute life-threatening symptoms for several hours. Discussion The BL histamine concentrations in this patient with mastocytosis are approximately 4 ng/mL, compared with a peak of 30
0 Comments Background Most patients with childhood-onset immune dysregulation, polyendocrinopathy, and enteropathy have no genetic diagnosis for their illness. These patients may undergo empirical immunosuppressive treatment with highly variable outcomes. Objective We sought to determine the genetic basis of disease in patients referred with Immune dysregulation, polyendocrinopathy, enteropathy, X-linked–like (IPEX-like) disease, but with no mutation in
0 Comments Lu H.Y. Bauman B.M. Arjunaraja S. Dorjbal B. Milner J.D. Snow A.L. et al. The CBM-opathies—a rapidly expanding spectrum of human inborn errors of immunity caused by mutations in the CARD11-BCL10-MALT1 complex. Front Immunol. 2019; 9: 2078 Lu H.Y. Biggs C.M. Blanchard-Rohner G. Fung S.Y. Sharma M. Turvey S.E. Germline CBM-opathies: from immunodeficiency to
0 Comments Footnotes This study was supported by the Biotechnology and Biological Sciences Research Council Studentship (BBSRC-NPIF studentship/BIDS3000032503) to Y.E.B. Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) was supported by an Innovative Medicines Initiative Joint Undertaking (no. 115010 ), resources from the European Union’s Seventh Framework Programme (FP7/2007-2019), and The European Federation of
0 Comments Background Mastocytosis is a risk factor for Hymenoptera venom anaphylaxis (HVA). Current guidelines recommend measuring tryptase in patients with HVA and that those with mastocytosis pursue lifelong venom immunotherapy (VIT). Available data on HVA and mastocytosis largely derive from European single-center studies, and the prevalence of HVA with and without mastocytosis in the United
0 Comments Inborn errors of immunity (IEI) are rare diseases, which makes diagnosis a challenge. A better description of the initial presenting manifestations should improve awareness and avoid diagnostic delay. Although increased infection susceptibility is a well-known initial IEI manifestation, less is known about the frequency of other presenting manifestations. Source link
0 Comments Footnotes Supported by the National Psoriasis Foundation Discovery Grant 2019 and in part by grant UL1TR001866 from the National Center for Advancing Translational Sciences and the National Institutes of Health Clinical and Translational Science Award program . Disclosure of potential conflict of interest: J. Kim has received research funds from AbbVie. E. Guttman-Yassky has
0 Comments Food and Agriculture Organization of the United Nations; World Health Organization; Codex Alimentarius Commission General standard for the labelling of prepackaged foods. 1985. () Prescott S.L. Pawankar R. Allen K.J. Campbell D.E. Sinn J.K.h. Fiocchi A. et al. A global survey of changing patterns of food allergy burden in children. World Allergy Organ J.
0 Comments Background Exosomes have emerged as a vital player in cell-cell communication; however, whether airway epithelial cell (AEC)-generated exosomes participate in asthma development remains unknown. Objective Our aims were to characterize the AEC-secreted exosomes and the potentially functional protein(s) that may contribute to the proinflammatory effects of AEC exosomes in the dendritic cell (DC)-dominant airway
0 Comments Considering that EMT and cytoskeleton remodeling are the prerequisite processes for cell migration, 43 Cancer invasion and the microenvironment: plasticity and reciprocity. , 44 Shankar J. Messenberg A. Chan J. Underhill T.M. Foster L.J. Nabi I.R. Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. we examined whether DEP exposure was responsible for
0 Comments Bonita R. Beaglehole R. Kjellstrom T. Basic epidemiology. World Health Organization, Geneva, Switzerland2006 Epidemiology: principles and methods. Little, Brown, and Company, Boston, MA1970 US Centers for Disease Control and Prevention () () Broder I. Higgins M.W. Mathews K.P. Keller J.B. Epidemiology of asthma and allergic rhinitis in a total community, Tecumseh, Michigan. IV. Natural
0 Comments People line up to get on the Air France flight to Paris at OR Tambo’s airport in Johannesburg, South Africa, on Nov. 26. The United States, Israel and other European nations have already imposed travel restrictions on South Africa and other nations in the region. Jerome Delay/AP hide caption toggle caption Jerome Delay/AP People
0 Comments Asthma is a chronic inflammation of the airways primarily mediated by exacerbated type 2 immune responses. 1 The immunology of asthma. , 2 Lloyd C.M. Snelgrove R.J. Type 2 immunity: expanding our view. Sex differences in asthma prevalence and phenotypes have been well described. 3 Carey M.A. Card J.W. Voltz J.W. Arbes Jr., S.J.